Diazepam in tetanus.

Neonatal tetanus treated with high dosage diazepam.

The combination of continuous intravenous infusion of diazepam (20--40 mg/kg per day) and intragastric phenobarbitone (10--15 mg/kg per day in 4 divided doses) was used to treat 19 cases of neonatal tetanus. Mortality was 2/19 (11%). This regimen was considered to have reduced the mortality and the need for artificial ventilation. The main side effects encountered were severe drowsiness, coma, ...

Tetanus in childhood: report of a therapeutic trial of diazepam.

The clinical management of tetanus poses a difficult therapeutic problem to physicians everywhere. Mortality from the disease remains high even in those medical centres endowed with the best facilities currently available. In many developing countries where the disease is prevalent, and medical services are inadequate for local needs, mortality figures are alarmingly high, especially among case...

Transient psychological syndrome following diazepam therapy for tetanus.

Two cases of transitory reversible pathopsychological changes associated with diazepam therapy in tetanus are described. The psychopathology developed owing to an abrupt discontinuance ofdiazepam or to a sudden reduction of its dosage. The reinstitution of diazepam in low doses and the administration of regulators of cerebral metabolism resulted in a progressive normalization of the psychologic...

Comparative clinical trial of diazepam with other conventional drugs in tetanus.

Results of therapeutic trial of diazepam in tetanus are presented. The trial included 200 cases of tetanus167 non-neonates and thirty-three neonates. The patients were divided into two groups and were matched as regards age, sex and severity of the disease. The cases of group I received standard treatment while the cases of group II received diazepam in addition. Over-all mortality in group I w...

Cranial nerve palsies in tetanus: cephalic tetanus.